pseudomonas exotoxin meaning in English

假单胞菌外毒素

Translocation from endocytic compartments to the cytosol is the essential and rate - limiting step in the intoxication process of most toxins such as ricin , diphtheria toxin , shiga toxin and pseudomonas exotoxin ( pe ) . a number of these toxins are transported to trans - golgi network ( tgn ) , and in many cases such transport to the tgn is required for the translocation and cytotoxicity . in deed , 5 % of the ricin endocytosed by cells has been shown to reach the tgn
蓖麻毒素进入细胞的机理不甚明了，一般认为是rtb先与细胞膜受体结合，主要经过受体介导的内吞作用进入吞噬体，然后沿着内体、高尔基体、内质网等逆向分泌途径，有序地运输到内质网，最后从内质网转位进入细胞浆，在胞浆内攻击核糖体，从而抑制蛋白质的合成，导致细胞死亡。